The first International conference Sofia Knowledge City was held successfully on 28 September in Capital Fort, Sofia, under the patronage of Sofia Municipality. The initiators and organizers of the event were Cluster Sofia Knowledge City and Investor Media Group. The conference aimed to attract the attention of citizens, business, scientific, educational institutions, and administration to the topic of the cities of knowledge and the opportunities that can be found in Sofia if the world trends are followed. Special attention was paid to the experience of the City of Vienna in knowledge management, the role, and importance of the specialized programs of the European Union, and the international initiatives in this field.